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Sunday, March 3, 2013
Send Some Dangerous Airmail With These Weaponized Paper Planes
Saturday, March 2, 2013
Backed By Reed Hastings & More, Gobstopper Launches Its E-Reading Platform For Schools To Help Rethink Humanities Education
As the founder of two KIPP public charter prep schools, an Entrepreneur-In-Residence at NewSchools Ventures and a former English teacher, Jason Singer is familiar with the starring role that technology is increasingly playing in the classroom. However, while the push to improve STEM education is alive and well, there's a tendency to forget about the other side. When it comes to basic reading and writing skills, American high school and college students aren't exactly making the grade.Source: http://feedproxy.google.com/~r/Techcrunch/~3/xUwP4lWIdQ0/
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Yahoo Does Some Spring Cleaning: Shuts Down Avatars, App ...
Yahoo, wh??h ?? now officially a technology companionship, ???t announced a Google-??k? spring cleaning campaign. J??t ??k? Larry Page ?t?rt?? shutting down a number ?f under-performing Google properties wh?n h? took over fr?m Eric Schmidt, Yahoo?s n?w CEO Marissa Mayer ?? ???? ?b??t t? shut down a number ?f smaller Yahoo properties. According t? now?s announcement, Yahoo w??? shut down ?t? BlackBerry app, Avatars, App Search, Sports IQ ?n? ?t? Message Boards website ?n April 1st. In addendum, ?t?s ending support f?r th? Yahoo Updates API ?n April 16th.
Wh??? ?t ?? shutting down th? Message Boards website, individual message boards ?n sites ??k? Yahoo! Finance ?n? Yahoo! Fantasy Sports w??? remain active. BlackBerry users w??? b? ?b?? t? continue t? ??? th? app, b?t ?t won?t b? m??? available f?r download ?ft?r April 1st.
If ??? h??? n? th???ht wh?t ??? ?f th??? products ?r?, ??? ?r? probably n?t alone. Yahoo Avatars, f?r example, ?? th? name implies, allowed ??? t? build ??? ?wn avatar ?n? th?n export ?t t? Facebook ?n? Twitter.
Virtually ??? ?f th? ?th?r products Yahoo ?? shutting down w?r? similarly underused, ?? chances ?r? th?r? won?t b? a major outcry over now?s closures.
A? Yahoo EVP ?f Platforms Jay Rossiter notes ?n th? announcement, th? companionship ?? m?k?n? th??? changes ? ?n ?n effort t? sharpen ??r focus. B? continuing t? home ?n ?n ??r core products ?n? experiences, w??ll b? ?b?? t? m?k? ??r existing products th? very best th?? ??n b?.?
Here ?? Yahoo?s full list ?f products th?t w??? ??t th? ax next month:
Yahoo! Avatars
Effective April 1, 2013, w? w??? n? longer support Yahoo! Avatars ??r??? ??r properties. If ??? ??k? ???r existing avatar ?n? want t? keep ?t, please ?? t? th? Avatars download page, pick a picture size ?n? format, ?n? click th? appropriate download button. Similarly, ?f ??? want t? edit ???r avatar, ??? ??n download th? image ?n? th?n ??? a photo control service ?f ???r preference. If ??? want t? continue using ???r avatar w?th ??r products, ?? t?Yahoo! Profile ?n? upload th? avatar ??? downloaded. F?r more details, please click here. Additionally effective April 1, w? w??? n? longer support th? Avatars YQL desk.Yahoo! app f?r BlackBerry
Effective April 1, 2013, th? Yahoo! app f?r BlackBerry w??? n? longer b? available f?r download. F?r those ?f ??? wh? h??? b? now downloaded th? app, ??? ??n continue t? ??? ?t b?t ?t w??? n? longer b? actively supported.Yahoo! Clues (beta)
Effective April 1, 2013, Yahoo! Clues (beta) w??? shut down.Yahoo! App Search
Effective April 1, 2013, Yahoo! App Search w??? shut down.Yahoo! Sports IQ
Effective April 1, 2013, Yahoo! Sports IQ w??? shut down. Y??r final lifetime Sports IQ score ?n? rank w??? b? automatically transferred t? ?n? preserved within ???r Yahoo! Fantasy Profile.Yahoo! Message Boards website
Effective April 1, 2013, th? Yahoo! Message Boards website w??? shut down. O?r message boards ?n individual properties (??k? Yahoo! Finance ?n? Yahoo! Fantasy Sports) w??? remain active. W? ???? encourage ??? t? q???t??n ?n? ?n?w?r q???t??n? ?n Yahoo! An?w?r?, ?n? discuss issues ?n th? comments section ?n Yahoo! News.Yahoo! Updates API
A? ?f April 16, 2013, w? w??? n? longer support th? Yahoo! Updates API.
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Rev. Dr. Cindi Love: Cedarville Baptists Send VP and President Packing
I want to give a big shout-out to The New York Times for its persistent and intriguing coverage of Christian colleges and universities in the United States that are sifting and sorting their theological and ministry positions on homosexuality and gender expression. And I want to thank Times writer Mark Oppenheimer for specifically mentioning that my beloved Soulforce was again blamed by the conservative Cedarville University trustees for raising the question of whether a person can be Christian and gay on their campus. As I mentioned in a previous blog post, those of us at Soulforce feel like we have done a good day's work when people have to think about and talk about what it means to be gay and Christian.
Cedarville's Vice President for Student Life, Dr. Carl Ruby, was a gracious host when we visited the campus in 2007. Unlike some school leaders who arrange to have our Riders arrested for trespassing when they try to speak about the Bible and homosexuality, Dr. Ruby allowed us on campus, organized a series of chapel talks about homosexuality and encouraged students to welcome us with love. Though Dr. Ruby persists in his belief that the Bible condemns homosexual acts, he thought that our visit was an opportunity to teach Cedarville students how to gracefully engage those with whom they may disagree.
It is Cedarville's loss that Dr. Ruby resigned under pressure last month. He was like a refiner's fire on the campus, helping "faculty, students and trustees at Cedarville try to figure out what kind of Christians they are." Oppenheimer writes, "Are they sectarian or broad-minded? Fundamentalist or open? Republicans, or independent of political parties? Those who want a less fundamentalist, more open Cedarville believe that Dr. Ruby is a martyr to their cause."
Cedarville University, founded in 1887, was affiliated with the General Association of Regular Baptist Churches, an insular fundamentalist organization that firmly legislated conduct of all kinds. Lately, though, liberalism has encroached upon their safe space. For example, some kinds of dancing are now allowed on campus. Some professors did not vote for Romney and told their students why not. And some resident theologians suggested that the creation story might not be literally true. But as Oppenheimer explains, "The departures of William Brown, the president, whose resignation is effective June 30, and of Dr. Ruby, are widely viewed as strengthening the hands of the most conservative trustees, fearful of a more open Cedarville."
Oppenheimer quotes the Rev. Chris Williamson, who resigned from the Cedarville board of trustees last month, as saying, "[The trustees] were threatened by Carl's approach not to theology but to ministry, in terms of his ministry to people struggling with gender identification, how he ministers to people on the margins." Dr. Ruby sounds just like Jesus to me, the radical includer.
For now, the conservative faction is having its way with Cedarville -- but not for long, I predict. Love trumps ignorance and exclusion. Dr. Ruby was a true educator and a compassionate Christian. He influenced students and faculty alike. He told them that he wanted them to be sincere engagers with the culture, just as Jesus instructed his disciples. If Cedarville wants to persist in its mission as a Christian institution, it will have to sort out what it means to really be Christian in the world. What does it mean to be trustworthy in the name of Christ?
I am grateful that Dr. Ruby was trustworthy in the ways that really matter. Rather than driving young people out of church and convincing them that God doesn't love them, he created a safe haven where they could be themselves and sort out their own beliefs without exclusion.
"In the end we all have to trust someone with our spirits and inner thoughts. Caution is wise is making this decision. A bad haircut grows out, but a broken spirit is slow to mend."
--Rev. Joshua Love, my son
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Follow Rev. Dr. Cindi Love on Twitter: www.twitter.com/SoulforceLove
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Friday, March 1, 2013
narrate cynicism: Grandparenting in Interfaith Families | Network ...
Are you a Jewish grandparent navigating your relationship with your child, their partner, and your grandchild? 
I believe step one should be to have a conversation. The grandparent should sit down with their adult child and discuss how each sees the other?s role. Share thoughts, feelings, hopes, and dreams. Respect each other. Recognize that this can be easier said than done!
But then what? Grandparents: what do you do (have you done) that has worked really well? What didn?t work so well that you would do differently next time? Children, what have your parents done that worked (or didn?t)? What do you wish they would do?
I have five ideas to get us started; I?m interested to hear if you think these will be well received.
- Celebrate a Jewish holiday with the other grandparents. For example, invite them to the Passover seder (along with your child?s family). Include them in your religious/cultural celebrations. Help them better understand Judaism and its rich traditions.
- Ask your child if they need support, resources, or guidance from you. Offer to assist them in the choices that they make. Being active in the Jewish community can be expensive; if you are in a position to help, offer to pay for religious school or summer camp (if your assistance would be appreciated).
- Offer to babysit, but make sure you?re transparent with your plans. Tell your child that you?d like to invite your grandchildren over for dinner on Friday night, light Shabbat candles, say the blessings, and enjoy a wonderful meal together. Attain quality time with your grandchildren and give their parents the night off for their own quality time together!
- Be visible in your grandchild?s life. Visit often if you can. Use modern technology like Skype to see and talk to your family if they live far away (or even if they are around the corner).
- Keep the dialogue open.
What would you like to add to this list?
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Source: http://www.interfaithfamily.com/blog/iff/grandparenting/grandparenting-in-interfaith-families/
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Source: http://narrate-cynicism.blogspot.com/2013/02/grandparenting-in-interfaith-families.html
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Video: Reading the human genome
Thursday, February 28, 2013
Researchers with the U.S. Department of Energy (DOE)'s Lawrence Berkeley National Laboratory (Berkeley Lab) have achieved a major advance in understanding how genetic information is transcribed from DNA to RNA by providing the first step-by-step look at the biomolecular machinery that reads the human genome.
"We've provided a series of snapshots that shows how the genome is read one gene at a time," says biophysicist Eva Nogales who led this research. "For the genetic code to be transcribed into messenger RNA, the DNA double helix has to be opened and the strand of gene sequences has to be properly positioned so that RNA polymerase, the enzyme that catalyzes transcription, knows where the gene starts. The electron microscopy images we produced show how this is done."
Says Paula Flicker of the National Institutes of Health's National Institute of General Medical Sciences, which partly funded the research, "The process of transcription is essential to all living things so understanding how it initiates is enormously important. This work is a beautiful example of integrating multiple approaches to reveal the structure of a large molecular complex and provide insight into the molecular basis of a fundamental cellular process."
Nogales, who holds joint appointments with Berkeley Lab, the University of California (UC) at Berkeley, and the Howard Hughes Medical Institute (HHMI), is the corresponding author of a paper describing this study in the journal Nature. The paper is titled "Structural visualization of key steps in human transcription initiation." Co-authors are Yuan He, Jie Fang and Dylan Taatjes.
The fundamental process of life by which information in the genome of a living cell is used to generate biomolecules that carry out cellular activities is the so-called "central dogma of molecular biology." It states that genetic information flows from DNA to RNA to proteins. This straightforward flow of information is initiated by an elaborate system of proteins that operate in a highly choreographed fashion with machine-like precision. Understanding how this protein machinery works in the context of passing genetic information from DNA to RNA (transcription) is a must for identifying malfunctions that can turn cells cancerous or lead to a host of other problems.
Nogales and members of her research group used cryo-electron microscopy (cryo-EM), where protein samples are flash-frozen at liquid nitrogen temperatures to preserve their structure, to carry out in vitro studies of reconstituted and purified versions of the "transcription pre-initiation complex." This complex is a large assemblage of proteins comprised of RNA polymerase II (Pol II) plus a class of proteins known as general transcription factors that includes the TATA-binding protein (TBP), TFIIA, TFIIB, TFIIF, TFIIE and TFIIH. All of the components in this complex work together to ensure the accurate loading of DNA into Pol II at the start of a gene sequence.
"There's been a lack of structural information on how the transcription pre-initiation complex complex is assembled, but with cryo-EM and our in vitro reconstituted system we've been able to provide pseudo-atomic models at various stages of transcription initiation that illuminate critical molecular interactions during this step-by-step process," Nogales says.
The in vitro reconstituted transcription pre-initiation complex was developed by Yuan He, lead author on the Nature paper and a post-doctoral student in Nogales's research group.
"This reconstituted system provided a model for the sequential assembly pathway of transcription initiation and was essential for us to get the most biochemically homogenous samples," Nogales says. "Also essential was our ability to use automated data collection and processing so that we could generate all our structures in a robust manner."
Among the new details revealed in the step-by-step cryo-EM images was how the transcription factor protein TFIIF engages Pol II and promoter DNA to stabilize both a closed DNA pre-initiation complex and an open DNA-promoter complex, and also how it regulates the selection of a transcription start-site.
"Comparing the closed versus open DNA states led us to propose a model that describes how DNA is moved during the process of promoter opening," says He. "Our studies provide insight into how THIIH uses ATP hydrolysis as a source of energy to actually open and push the DNA to the active site of Pol II."Nogales and her colleagues plan to further investigate the process of DNA loading into Pol II, as well as to include additional transcription factors into the assembly that are required for regulation of gene expression.
"Our goal is to actually build a structural model of the entire - more than two million daltons - protein machinery that recognizes and regulates all human DNA promoters," Nogales says. "For now we have the structural framework that's been needed to integrate biochemical and structural data into a unified mechanistic understanding of transcription initiation."
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DOE/Lawrence Berkeley National Laboratory: http://www.lbl.gov
Thanks to DOE/Lawrence Berkeley National Laboratory for this article.
This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.
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Source: http://www.labspaces.net/127057/Video__Reading_the_human_genome
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